About Our Research
The Rao Lab focuses on non-coding RNA in hematopoietic development and cancer.
The control of hematopoietic differentiation and its dysregulation in leukemia is complex- and many newly discovered elements of gene expression regulation play important roles. We have recently made some important inroads into microRNA- and long non-coding RNA- dependent regulation of B-cell differentiation and leukemogenesis. Our research points to critical roles played by non-traditional modes of gene regulation in hematopoiesis and cancer. It's our goal to understand these roles and to determine how we can leverage these novel mechanisms in the diagnosis and treatment of human diseases.
The following topics are currently being explored in the lab:
- Single Cell Studies of microRNA function
- RNA binding proteins in hematopoiesis
- Non-coding RNA in leukemia
- microRNAs in oncogenic pathways
- Long non-coding RNA in leukemia
- Hematopoietic roles of microRNA
Text from the Rao Lab website: http://pathology.ucla.edu/site.cfm?id=759