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BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia PDF available through Get Fulltext Research

Ni, Rodríguez-Malavé Thilini Fernando Pc, Patel Jorge Contreras Jk, Palanichamy Tiffany Tran Jaime Anguiano Mj, Davoren Mo, Alberti Kt, Pioli ...

Published in Molecular Cancer

Background A new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development and oncogenesis. Gene expression profiling of human B-ALL samples showed differential lncRNA expression in samples with particular ...

MicroRNA-146a modulates B-cell oncogenesis by targeting Egr1

Jorge Contreras Jk, Palanichamy Tiffany Tran Thilini Fernando Ni, Rodriguez-Malave Va, Arboleda D, Casero Dinesh S. Rao

Published in Oncotarget

miR-146a is a NF-κB induced microRNA that serves as a feedback regulator of this critical pathway. In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-κB activity. In this study, we queried whether the deficiency of miR-146a contributes to B-cell oncogenesis. Combining miR-146a defic...

Long non-coding RNA in hematologic malignancies

Rodriguez-Malave, Ni Dinesh S. Rao

Published in Briefings in Functional Genomics

Vectored Immunoprophylaxis Protects Humanized Mice from Mucosal HIV Transmission”

Balazs, Ab Ouyang, Y Hong, Cm Chen, J Nguyen, Sm Dinesh S. Rao An, Ds Baltimore, D

Published in Nature Medicine

Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-?B Gene Network

Fang, J Barker, B Bolanos, L Liu, X Jerez, A Makishima, H Christie, S Chen, X Dinesh S. Rao Grimes, Hl ...

Published in ” Cell Rep

“miRNA dysregulation in cancer: towards a mechanistic understanding”

Palanichamy, Jk Dinesh S. Rao

Published in Frontiers in Genetics. Mar

Broad protection against influenza infection by vectored immunoprophylaxis in mice PDF available through Get Fulltext Research

Balazs, Alejandro B Bloom, Jesse D Hong, Christin M Rao, Dinesh S Baltimore, David

Published in Nature Biotechnology

Neutralizing antibodies that target epitopes conserved among many strains of influenza virus have been recently isolated from humans. Here we demonstrate that adeno-associated viruses (AAV) encoding two such broadly neutralizing antibodies are protective against diverse influenza strains. Serum from mice that received a single intramuscular AAV inj...

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice PDF available through Get Fulltext Research

Zhao, Jimmy L Dinesh S. Rao O’connell, Ryan M Garcia-Flores, Yvette Baltimore, David

Published in eLife

During inflammation and infection, hematopoietic stem and progenitor cells are stimulated to proliferate and differentiate into mature immune cells, especially of the myeloid lineage. MicroRNA-146a (miR-146a) is a critical negative regulator of inflammation. Deletion of miR-146a produces effects that appear as dysregulated inflammatory hematopoiesi...

A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rea...

Tirado, Ca Shabsovich, D Denicola, M Dinesh S. Rao Yang, L Garcia, R Rao, N

Published in ” Biomark Res

MiR-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation

Pigazzi, M Manara, E Bresolin, S Tregnago, C Beghin, A Baron, E Giarin, E Cho, Ec Masetti, R Dinesh S. Rao ...

Published in Cardiovascular & Hematological Agents in Medicinal Chemistry

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