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MicroRNA-146a modulates B-cell oncogenesis by targeting Egr1

Jorge Contreras Jk, Palanichamy Tiffany Tran Thilini Fernando Ni, Rodriguez-Malave Va, Arboleda D, Casero Dinesh S. Rao

Published in Oncotarget

miR-146a is a NF-κB induced microRNA that serves as a feedback regulator of this critical pathway. In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-κB activity. In this study, we queried whether the deficiency of miR-146a contributes to B-cell oncogenesis. Combining miR-146a defic...

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